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. 2021 Jun 29;10(13):e020331. doi: 10.1161/JAHA.120.020331

Figure 1. Forest plot depicting Mendelian randomization estimates for the association of genetically proxied GLP1R (glucagon‐like peptide receptor) agonism and glycemic control more generally with (A) risk of heart failure (HF; 47 309 cases/930 014 controls) and (B) left ventricular ejection fraction (LVEF; n=16 923).

Figure 1

Estimates reflect the effect of a reduction in glycated hemoglobin on each of the respective outcomes (so as to orient estimates to GLP1R agonist drug effects). Squares correspond to point estimates, and the surrounding lines correspond to 95% CIs. diff indicates difference; and OR, odds ratio.