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Hypersensitivity to IFN cytotoxicity of Shp-2−/− fibroblast cells. Wild-type and Shp-2−/− cells were treated with various concentrations of IFN-α or IFN-γ for 96 h. Surviving cells were quantitated by crystal violet staining assay. Data shown are the means of three independent experiments ± standard deviations. The percentage of cell survival (surv) was defined as the relative number of treated versus untreated cells.
