Table 2.
Clinical outcomes at W8 compared to D0
| Outcome | D0 | W8 | p value |
|---|---|---|---|
| Vaginal mucosa thickness (N = 19) | |||
| Superficial | |||
| Median | 28.41 | 26.36 | p = 1 |
| IQR | 17.31; 38.78 | 21.5; 35.89 | |
| Range | 10.13; 116.88 | 10.6; 102.12 | |
| Intermediate | |||
| Median | 114.4 | 112.5 | p = 0.6507 |
| IQR | 85.58; 141.74 | 71.76; 162.12 | |
| Range | 40.6; 230.53 | 36.19; 237.26 | |
| Basal | |||
| Median | 70.28 | 83.25 | p = 0.8596 |
| IQR | 59.1; 103.79 | 63.78; 89.77 | |
| Range | 36.61; 128.23 | 36.69; 116.96 | |
| Total | |||
| Median | 213.65 | 212.33 | p = 0.5949 |
| IQR | 139.33; 300.76 | 175.09; 261.58 | |
| Range | 97.66; 439.7 | 86.65; 456.33 | |
| Vaginal Flora (N = 11) | |||
| Nugent score | |||
| Median | 5 | 5 | p = 0.5469 |
| IQR | 3; 7 | 3; 5 | |
| Range | 2; 8 | 1; 7 | |
| Vaginal pH | |||
| Vicinity of the injected area (N17) | |||
| Median | 6 | 5.5 | p = 0.0574 |
| IQR | 5.5; 6.5 | 5; 6 | |
| Range | 5; 7.5 | 4.5; 7 | |
| Lateral vaginal pouch (N = 19) | |||
| Median | 6 | 5.5 | p = 0.0955 |
| IQR | 5.5; 7 | 4.5; 6.5 | |
| Range | 4; 7.5 | 4.5; 7.5 | |
| Bachman VHI (N = 18) | |||
| VHI | |||
| Median | 12 | 21 | p < 0.0001 |
| IQR | 10; 16 | 17; 22 | |
| Range | 5; 17 | 12; 25 | |
| Procollagen I and III proteins mean fluorescence intensity/μm2 (N = 19) | |||
| Procollagen I mean fluorescence intensity/μm2 | |||
| Median | 47.87 | 61.91 | p = 0.9843 |
| IQR | 35; 72.71 | 27.3; 82.78 | |
| Range | 16.06; 146.87 | 8.01; 145 | |
| Procollagen III mean fluorescence intensity/μm2 | |||
| Median | 11.99 | 10.49 | p = 0.7086 |
| IQR | 3.32; 27.36 | 4.6; 20.71 | |
| Range | 0.27; 72.27 | 0.7; 60.13 | |
| COL1A1 and COL3A1 gene expression N = 19 | |||
| COL1A1/GAPDH | |||
| Median | 0.0035 | 0.0168 | p = 0.0002 |
| IQR | 0.0014; 0.0053 | 0.0091; 0.0403 | |
| Range | 0.0006; 0.0151 | 0.0012; 0.1178 | |
| COL3A1/GAPDH | |||
| Median | 0.0003 | 0.0009 | p = 0.0010 |
| IQR | 0.0002; 0.0005 | 0.0004; 0.0025 | |
| Range | 0.0001; 0.0012 | 0.0001; 0.0068 | |
| Mitotic activity of the mucosa (Ki67) N = 19 | |||
| Ki67 positive nucleus mean/mm2 | |||
| Median | 229.4 | 195.09 | p = 0.8288 |
| IQR | 114.54; 426.16 | 76.76; 463.05 | |
| Range | 5.4; 695.26 | 0; 668.75 | |