Table 3.
Basic and cycle characteristics and pregnancy outcomes in the different controlled ovarian stimulation protocols in Group 3
| Variable | GnRH Antagonist(A) | Long GnRH-a(B) | GnRH-a ultra-long(C) | Overall p value | A vs B | A vs C | B vs C |
|---|---|---|---|---|---|---|---|
| Number of patients, n (%) | 414(92.8) | 12(2.7) | 20(4.5) | ||||
| Maternal age, y | 33.21 ± 4.80 | 34.08 ± 4.30 | 31.80 ± 4.94 | 0.328 | |||
| Body mass index, kg/m2 | 21.74 ± 2.87 | 21.73 ± 2.61 | 21.85 ± 2.38 | 0.965 | |||
| Baseline FSH, mIU/mL | 8.62 ± 2.80 | 7.18 ± 1.55 | 7.53 ± 2.15 | 0.030 | 1.00 | 0.134 | 0.221 |
| Antral follicle count (AFC) | 3.32 ± 0.91 | 3.17 ± 1.40 | 3.25 ± 1.33 | 0.828 | |||
| AMH level, ng/ml | 2.38 ± 1.32 | 4.01 ± 2.45 | 3.28 ± 1.75 | 0.002 | 0.044* | 0.025* | 1.00 |
| Duration of infertility, years, median (IQR) | 3.00(2.00–5.00) | 3.00(1.00–4.00) | 2.00(1.00–4.00) | 0.276 | |||
| Infertility diagnosis | 0.224 | ||||||
| Primary infertility, % | 56.8(235/414) | 66.7(8/12) | 75.0(15/20) | ||||
| Secondary infertility, % | 43.2(179/414) | 33.3(4/12) | 25.0(5/20) | ||||
| Gn duration, days | 9.45 ± 1.60 | 10.00 ± 1.48 | 11.35 ± 1.60 | < 0.001 | 0.703 | < 0.001* | 0.131 |
| Gonadotropin dose, IU | 2777 ± 698 | 2741 ± 731 | 3291 ± 860 | 0.013 | 1.00 | 0.010* | 0.118 |
| E2 on hCG day, pg/mL | 1917 ± 971 | 3817 ± 2712 | 2180 ± 1243 | 0.024 | 0.024* | 1.00 | 0.308 |
| P on hCG day, ng/mL | 0.82 ± 0.44 | 1.00 ± 0.39 | 0.99 ± 0.43 | 0.042 | 0.203 | 0.214 | 1.00 |
| No. of oocytes retrieved | 6.77 ± 3.54 | 9.58 ± 5.33 | 8.85 ± 4.21 | 0.015 | 0.150 | 0.086 | 1.00 |
| No. of MII oocytes | 6.03 ± 3.30 | 9.33 ± 5.50 | 7.55 ± 3.44 | 0.015 | 0.077 | 0.161 | 1.00 |
| Oocyte maturation rate | 0.89 ± 0.15 | 0.96 ± 0.08 | 0.88 ± 0.14 | 0.218 | |||
| The number of 2PN | 4.19 ± 2.76 | 6.42 ± 4.06 | 4.65 ± 2.98 | 0.090 | |||
| Normal fertilization rate | 0.65 ± 0.26 | 0.70 ± 0.19 | 0.56 ± 0.22 | 0.124 | |||
| blastocyst formation rate | 0.61 ± 0.35 | 0.52 ± 0.37 | 0.66 ± 0.24 | 0.686 | |||
| No. of available embryos | 4.17 ± 2.72 | 6.58 ± 3.58 | 4.70 ± 2.60 | 0.028 | 0.041* | 0.798 | 0.604 |
| Available embryo rate | 0.66 ± 0.29 | 0.73 ± 0.15 | 0.57 ± 0.21 | 0.137 | |||
| No. of embryos transferred | 0.93 ± 0.75 | 1.00 ± 0.85 | 1.10 ± 0.91 | 0.631 | |||
| Endometrial thickness, mm | 10.81 ± 2.49 | 11.23 ± 2.21 | 12.18 ± 2.52 | 0.032 | 1.00 | 0.038* | 1.00 |
| Cumulative live birth rate, % | 35.5(147/414) | 58.3(7/12) | 40.0(8/20) | 0.255 | |||
| Live birth rate, %b | 23.0(95/413) | 41.7(5/12) | 25.0(5/20) | 0.289 | |||
| Live birth rate, %c | 33.6(95/283) | 62.5(5/8) | 38.5(5/13) | 0.208 | |||
| Clinical pregnancy rate, %b | 27.8(115/414) | 41.7(5/12) | 30.0(6/20) | 0.510 | |||
| Clinical pregnancy rate, %c | 40.5(115/284) | 62.5(5/8) | 46.2(6/13) | 0.432 |
* Significant differences after Bonferroni correction (P < 0.05)
b Per started cycle
c Per embryo transfer