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. Author manuscript; available in PMC: 2021 Nov 5.
Published in final edited form as: Nature. 2021 May 5;593(7860):591–596. doi: 10.1038/s41586-021-03526-y

Extended Data Figure 5. The replication-stress response, likely caused by lrr-1 and nucleotide insufficiency, promotes cell extrusion.

Extended Data Figure 5

a-d, Confocal fluorescence micrographs showing the localization of RPA-1::YFP in ABplpappap (arrowhead) in ced-3(lf); ltIs44[Ppie-1::mCherry::PH]; opIs263[Prpa-1::rpa-1::YFP] embryos after the indicated RNAi treatment. Inset, magnified view of ABplpappap. A, anterior; R, right. e, Genes identified as suppressors of the sterility of lrr-1(lf) mutants (ref. 19) were tested for suppression of cell extrusion. f, Nomarski micrograph showing cells extruded (arrow) from a wild-type embryo after gmpr-1(RNAi) treatment. Scale bars, 10 μm.