Extended Data Table 1. Penetrances of the Tex phenotype produced by RNAi against cell cycle genes (and non-cell-cycle cyclins and CDKs) in ced-3(lf) animals.
Tex penetrance produced by indicated RNAi treatment, mammalian homolog of the RNAi target and whether or not the RNAi clone produced extensive lethality are shown. Genes corresponding to RNAi clones that produced more than 9% penetrance of the Tex phenotype are in bold. cyb-3 did not fit this criterion, as extensive lethality prevented the counting of sufficient number of animals to assign significance. Some cyclins and CDKs that function outside the cell cycle were included and served as negative controls.
| RNAi target | Mammalian Homolog | %Tex | n | extensive lethality? |
|---|---|---|---|---|
| empty vector | - | 1 | 159 | N |
| atl-1 | ATR | 10 | 509 | N |
| cdc-14 | CDC14 | 1 | 168 | N |
| cdc-25.1 | CDC25 | 0 | 111 | Y |
| cdc-25.2 | CDC25 | 12 | 159 | N |
| cdc-25.3 | CDC25 | 2 | 168 | N |
| cdc-25.4 | CDC25 | 0 | 183 | N |
| cdk-1 | CDK1 | 15 | 61 | Y |
| cdk-11.1 | CDK11 | 0 | 175 | N |
| cdk-11.2 | CDK11 | 1 | 132 | N |
| cdk-12 | CDK12 | 0 | 167 | N |
| cdk-2 | CDK2 | 65 | 181 | N |
| cdk-4 | CDK4 | 1 | 193 | N |
| cdk-5 | CDK5 | 0 | 155 | N |
| cdk-7 | CDK7 | 0 | 130 | Y |
| cdk-8 | CDK8 | 1 | 186 | N |
| cdk-9 | CDK9 | 1 | 155 | Y |
| cdt-1 | CDT1 | 1 | 147 | Y |
| chk-1 | CHEK1 | 10 | 164 | Y |
| cit-1.1 | CCNT1/2 | 0 | 105 | N |
| c it-1.2 | CCNT1/2 | 1 | 244 | N |
| cki-1 | CDKN1 | 0 | 125 | N |
| cki-2 | CDKN1 | 1 | 216 | N |
| clk-2 | TEL02 | 1 | 156 | N |
| cul-1 | CULI | 5 | 81 | Y |
| cul-2 | CUL2 | 0 | 21 | Y |
| cul-3 | CUL3 | 5 | 151 | Y |
| cul-4 | CUL4 | 0 | 141 | N |
| cya-1 | CCNA | 20 | 309 | N |
| cyb-1 | CCNB1 | 4 | 136 | N |
| cyb-2.1 | CCNB2 | 1 | 102 | N |
| cyb-2.2 | CCNB2 | 0 | 144 | N |
| cyb-3 | CCNB3 | 14 | 7 | Y |
| cic-1 | CCNC | 1 | 158 | N |
| cyd-1 | CCND | 0 | 111 | N |
| cye-1 | CCNE | 89 | 133 | Y |
| cyh-1 | CCNH | 0 | 119 | Y |
| cyl-1 | CCNL | 1 | 106 | Y |
| cyy-1 | CCNY | 1 | 108 | N |
| dpl-1 | TFDP1 | 0 | 167 | N |
| efl-1 | E2F | 0 | 141 | N |
| emb-27 | CDC16 | 0 | 107 | Y |
| emb-30 | ANAPC4 | 0 | 130 | Y |
| fzr-1 | FZR1 | 1 | 146 | N |
| fzy-1 | CDC20 | 0 | 130 | Y |
| hpr-17 | RAD 17 | 5 | 214 | N |
| hus-1 | HUS1 | 0 | 132 | N |
| lin-15 | - | 1 | 104 | N |
| lin-23 | βTrCP | 23 | 147 | N |
| lin-35 | Rb | 0 | 134 | N |
| lin-36 | - | 0 | 111 | N |
| lin-9 | LIN9 | 1 | 125 | N |
| mat-1 | CDC27 | 0 | 80 | Y |
| mat-2 | ANAPC1 | 1 | 163 | Y |
| mat-3 | CDC23 | 0 | 108 | Y |
| mdf-1 | MAD1L1 | 3 | 112 | N |
| mdf-2 | MAD2L1 | 1 | 111 | N |
| mrt-2 | RADI | 0 | 114 | N |
| rnr-1 | RRM1 | 5 | 103 | Y |
| san-1 | BUB1B | 1 | 145 | N |
| wee-1.1 | PKMYT1 | 1 | 159 | N |
| wee-1.3 | PKMYT1 | 0 | 60 | Y |