Table 2. A summary of the different approaches directed against myocilin for treating myocilin associated glaucoma.

Method	Mode of Action	References
Treatment with chemical chaperones	Relieve ER stress by promoting folding of mutant myocilin	Yam et al. 2007 [146], Burns et al. 2016 [145], Zode et al. 2011 [147], Zode et al. 2012 [148]
CRISPR-Cas9 mediated gene editing	Cutting the expression of mutant myocilin	Jain et al. 2017 [76]
Inhibiting myocilin aggregation	Small molecules promoting stability and preventing myocilin aggregation	Orwig et al.. 2014 [149]
Inhibition of grp94-myocilin interaction	Promoting clearance of mutant myocilin via autophagy	Stothert et al. 2014 [114], Crowley et al. 2016 [115], Stothert et al. 2017 [117], Huard et al. 2018 [116],