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The CIS/SOCS family. (A) Basic structures of the CIS/SOCS family proteins. (B) CIS1, SOCS1, and SOCS3 are induced by STATs. CIS inhibits STAT5 activation by binding to the receptor, SOCS1 directly binds to JAK, and SOCS3 binds to both the gp130-related receptors and JAK. (C) Amino acid sequences of kinase inhibitory region (KIR) of SOCS1 of various species. The figures are modified from Ref. 58.
