Table 5.
Summary of Evidence on Radiotherapy with or without Chemotherapy Followed by Brachytherapy
| Author and Year | Clinical Stages | Interventions | Follow-Up | Outcomes |
|---|---|---|---|---|
| Santos 201739 | III IV |
(n=24): EBRT up to 60 Gy + CT followed by HDR-BT | 44 M | OS [3 Y]: 68% OS [4 Y]: 68% CSS [3 Y]: 75% CSS [4 Y]: 68% LC [3 Y]: 80% LC [4 Y]: 80% LRC [3 Y]: 84% LRC [4 Y]: 76% DFS [3 Y]: 62% DFS [4 Y]: 48% |
| Takácsi-Nagy 201344 | I II III IV |
(n=60): EBRT up to 70 Gy ± CT with cisplatin followed by HDR-BT up to 30 Gy | 121 M | OS [5Y]: 47% LRC [5Y]: 50% LC [5Y]: 57% CSS [5Y]: 61% |
| Vedasoundaram 202046 | III | (n=57): EBRT 50 Gy + CT with cisplatin followed by HDR-BT up to 21 Gy | 60 M | CR: 77.2% |
Abbreviations: CT, chemoradiotherapy; CR, complete response; CSS, cancer specific survival; DFS, disease-free survival; EBRT, external beam radiotherapy; HDR-BT, high dose rate brachytherapy; LC, local control; LRC, locoregional control; M, months; OS, overall survival; RT, radiotherapy; Y, years.