Table 3.
Correlation of prostate KLK3 mRNA expression to clinical parameters in tumors from Decipher® (n = 6577).
| r | p | n | ||||
|---|---|---|---|---|---|---|
| KLK3 | Preop cPSA | KLK3 | Preop cPSA | KLK3 | Preop cPSA | |
| pathgs p | −0.1409 | 0.1211 | 6.12E-26 | 7.77E-12 | 6076 | 3861 |
| pathgs s | −0.0918 | 0.0467 | 1.32E-10 | 2.58E-01 | 6076 | 3861 |
| preop cpsa | −0.0470 | 1.0000 | 2.51E-02 | 0.00E+00 | 5994 | 5994 |
| age | −0.0061 | 0.0005 | 1.00E + 00 | 9.76E-01 | 6577 | 4347 |
| svi | −0.1784 | 0.2177 | 2.71E-44 | 1.13E-46 | 6365 | 4242 |
| epe | −0.0747 | 0.1269 | 3.32E-07 | 1.02E-16 | 6384 | 4252 |
| sm | 0.0102 | 0.0772 | 1.00E + 00 | 3.84 E-07 | 6487 | 4310 |
| lni | −0.1063 | 0.1928 | 5.65E-14 | 1.32E-34 | 5883 | 3975 |
| clings p | −0.1627 | 0.2017 | 4.40E-11 | 3.72E-16 | 2000 | 1600 |
| clings s | −0.1084 | 0.1426 | 1.40E-04 | 1.00E-08 | 2000 | 1600 |
| bcr | −0.1980 | 0.1278 | 1.45E-13 | 9.06E-07 | 1626 | 1468 |
| bcr time | 0.0312 | −0.1098 | 1.00E + 00 | 3.33E-05 | 1578 | 1422 |
| met | −0.1671 | 0.1206 | 2.00E-09 | 3.6E-06 | 1626 | 1468 |
| met time | −0.1563 | −0.0213 | 3.32E-07 | 4.21E-01 | 1447 | 1422 |
| pcsm | −0.2029 | 0.1164 | 1.23E-12 | 2.62E-05 | 1447 | 1298 |
| pcsm time | −0.2321 | 0.0427 | 3.05E-15 | 1.24E-01 | 1315 | 1297 |
| capra s | −0.0690 | 0.5035 | 1.00E + 00 | 2.40E-69 | 1062 | 1062 |
| adt | −0.2317 | 0.1935 | 1.55E-14 | 6.53E-12 | 1261 | 1239 |
| rt | −0.0255 | 0.0588 | 1.00E + 00 | 2.66E-02 | 1446 | 1421 |
| adt a | −0.0172 | 0.2103 | 1.00E + 00 | 4.27E-09 | 780 | 765 |
| adt s | −0.1563 | 0.1283 | 1.60E-05 | 1.71E-05 | 1131 | 1116 |
| rt a | 0.0736 | 0.0094 | 1.00E + 00 | 7.80E-01 | 910 | 888 |
| rt s | 0.0053 | 0.0340 | 1.00E+00 | 1.20E-01 | 1446 | 1421 |
| KLK3 | 1.0000 | −0.0470 | 0.00E+00 | 2.73E-04 | 8626 | 5994 |
| TotalPathGS | −0.1702 | 0.1186 | 1.05E-40 | 1.44E-13 | 6076 | 3861 |
| TotalClinGS | −0.1768 | 0.2256 | 1.63E-15 | 6.64 E-20 | 2000 | 1600 |
| Numeric pstage | −0.1811 | 0.1692 | 1.14E-45 | 1.13E-26 | 6034 | 3939 |
| Numeric cstage | −0.0614 | 0.1793 | 2.82E-02 | 1.04E-09 | 1277 | 1143 |
Abbreviations: bbpathgs_p: primary pathological Gleason score; pathgs_s: secondary pathological Gleason score; preop_psa: preoperative psa;; svi: seminal vesicle invasion; epe: extra prostatic extension: sm: urgical margins; lni: lymph node invasion: clings_p: primary clinical Gleason score; clings_s: secondary clinical Gleason score; bcr: biochemical recurrence (0=no; 1=yes); bcr_time: time from RP to biochemical recurrence; met: metastasis (0=no; 1=yes); met_time: time from RP to metastasis; pcsm: prostate cancer specific mortality (0=no; 1=yes); pcsm_time: time from RP to pcsm; capra_s: CAPRA_S nomogram score; adt: androgen deprivation therapy received (0=no; 1=yes); rt: radiation therapy received (0=no; 1=yes); adt_a: adjuvant adt received (0=no; 1=yes); adt_s: salvage adt received (0=no; 1=yes); rt_a: adjuvant rt received (0=no; 1=yes); rt_s: salvage rt received (0=no; 1=yes). PathGS: pathological Gleason score; ClinGS: clinical Gleason score; pstage: pathological tumor stage; cstage: clinical tumor stage.