Fig. 23.

Maximum-likelihood tree of hybrid PKS-NRPS enzymes involved in cytochalasan biosynthesis, rooted with enzymes involved in biosynthesis of equisetin-like compounds. Hypoxylaceae homologues are highlighed in red. The paralogous Ace1 and Syn2 hybrids from Pyricularia oryzae, and PyiS from P. grisea, are highlighted in green, orange and purple respectively. Clades are coloured to highlight paralogy. The Ace1 clade can be further divided into two sub-clades of paralogues (light and dark green). Clades with distant uncharacterised homologues of cytochalasan synthases are collapsed. Branch support indicated is the result of ultrafast bootstrap. Only support values above 95 % are deemed significant.