Fig. 7.

Proposed biosynthetic pathway for azaphilone diversification in the Hypoxylaceae. A; group A azaphilone biosynthesis. Enzymes responsible for diversification are highlighted in blue fonts. Lenormandin-type B refers to long-chain lenormandins lacking a third ring. B; cohaerin-type azaphilone biosynthesis. AT: acyltransferase, FAS: fatty acid synthase, hrPKS: highly reducing polyketide synthase, KR: trans-ketoreductase, MO: FAD-dependent monooxygenase, nrPKS: non-reducing polyketide synthase, OAS: orsellinic acid synthase, OxR: oxidoreductase.