Fig. 9.
Biosynthetic scheme for the formation of dihydroxynaphthalenes (DHN) and related dimeric structures in the Hypoxylaceae. Binaphthyl and benzo[j]fluoranthenes diversity is probably determined by the selectivity of the laccase PfamD, which supposedly can accept DHN but also various pathway intermediates for dimerisation. AT: acyltransferase, MT: methyltransferas, PfmaE: nrPKS, PfamG: tetrahydroxynaphthalene (T4HN) reductase, SD: scytalone dehydratase, T3HNR: trihydroxynaphthalene (T3HN) reductase.