Table 3.

protective effects of licorice on MTX-induced changes on serum proteins.

	Total proteins (g/dl)	Albumin (g/dl)	Globulins (g/dl)	IL-1β (pg/ml)	Il-6 (pg/ml)
Control	7.8± 0.56	4.1 ± 0.38	4.65 ± 0.39	134 ± 9.1	71 ± 7
Licorice	7.4 ± 0.56	3.5 ± 0.7	4.1± 0.61	156.3 ± 11.5	77 ± 9.5
Methotrexate	3.8 ± 0.3*	1.99 ± 0.4*	1.85 ± 0.05*	340 ± 35*	210 ± 24*
Licorice + methotrexate	5.7 ± 0.3**	3.02± 0.26**	4.5 ± 0.05**	168.2 ± 16**	110± 9.9**

Values are means ± standard error (SEM) for seven different mice per each treatment. Values are statistically significant at ^*P < 0.05 versus control and licorice groups. ^**P < 0.05 versus methotrexate.