Plasma concentrations were compared between patients with treatment success and those with treatment failure at 6 months after FAM therapy for (A) MMP-9, (B) MMP-3 and (C) YKL-40. (D) Receiver operating characteristic curves in predicting treatment failure at 6 months after FAM therapy. (E) Overall survival was compared according to MMP-9 concentrations before FAM therapy. The horizontal lines indicate means, and error bars indicate standard deviations. P values were derived from t-test. SD, standard deviation; AUC, area under the curve; CI, confidence interval.