Table 2.
Stroke risk per interquartile range (IQR = 0.19) difference and quartile of urinary cadmium concentration (creatinine standardized).
| Cd Variable | Total | Cases (n) | Urinary Cd Median μg/g | Model 1 a HR (95% CI) | Model 2 b HR (95% CI) | Model 3 c HR (95% CI) | Trend Test P-value |
|---|---|---|---|---|---|---|---|
| Continuous | 1689 | 534 | 0.204 | 1.02 (0.92-1.12) | 1.02 (0.92-1.12) | 1.02 (0.93-1.13) | 0.56 |
| Quartile 1 | 403 | 119 | 0.098 | Ref | ref | Ref | |
| Quartile 2 | 423 | 132 | 0.166 | 1.05 (0.77-1.41) | 1.03 (0.76-1.39) | 1.03 (0.76-1.40) | |
| Quartile 3 | 422 | 136 | 0.250 | 1.10 (0.81-1.50) | 1.10 (0.81-1.49) | 1.10 (0.81-1.50) | |
| Quartile 4 | 441 | 147 | 0.436 | 1.11 (0.79-1.54) | 1.09 (0.78-1.52) | 1.11 (0.79-1.55) |
a
Model with age as time axis and adjusted for gender.
b
Model 1 with additional adjustment for cotinine (continuous).
c
Fully adjusted model: Model 2 with additional adjustment for BMI (continuous) and education (categorical).