Table 1.
The mammalian endogenous repressors of Wnt/β-catenin signaling
| Factors | Targets | Inhibitor/activator of the target | Mechanism | Reversible or irreversible | References |
|---|---|---|---|---|---|
| Dkks | Lrp | Inhibitor | Competitive combination | Reversible | 407,408 |
| Sfrp | Wnt, Fzd | Inhibitor | Competitive combination | Reversible | 409,410 |
| Wif | Wnt | Inhibitor | Competitive combination | Reversible | 411 |
| Sost | Lrp | Inhibitor | Competitive combination | Reversible | 412 |
| Cerberus | Wnt | inhibitor | Competitive combination | Reversible | 413 |
| Wise | LRP5/6 | inhibitor | Competitive combination | Reversible | 414 |
| IGFBP-4 | LRP6, Fzd | inhibitor | Competitive combination | Reversible | 415 |
| Wingful/Notum | Wnt | Inhibitor | Deacetylation, oxidization | Irreversible | 416 |
| Tiki | Wnt | Inhibitor | Cleavage, oxidization | Irreversible | 417 |