Skip to main content
. 2021 Aug 8;297(3):101068. doi: 10.1016/j.jbc.2021.101068

Figure 6.

Figure 6

DNA damage, repair, gene expression, and epigenomic markers for Per1.Per1 is significantly upregulated after cisplatin treatment across all four organs. RNA-seq plus and minus cisplatin (cisp. and cont., respectively) is shown in gray at the top for each organ. Damage-seq and XR-seq data are shown for both strands. Pt-d(GpG) damage (Damage-seq) and repair (XR-seq) distribution on the TS and NTS are shown with − and +, respectively. Epigenetic data from ChIP-seq of H3K4me3 and H3K27me3, as well as DNase-seq, are plotted at the bottom of each organ. We show that the transcriptional and epigenomic profiles of Per1 and neighboring regions across all four organs recapitulate the differences in DNA damage and repair between the TS and NTS. Adapted with permission from Yimit et al. (102).