Figure 9.

XR-seq analysis of repair in circadian-controlled genes. The screenshot shows repair profiles for the circadian-controlled gene, Npas2, which has a peak expression at ZT22. Repair of the rhythmic Npas2 gene exhibits high amplitude transcribed strand (TS) (−s) repair peaks at 2 h, ∼24 h, and ∼48 h after drug injection. Only after 48 h does the nontranscribed strand (NTS) become the main source of repair product from the Npas2 gene. RPKM reads per kilobase per million reads. Adapted with permission from Yang et al. (104).