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The computer-designed 3D-printed PCL scaffold customized for guided bone formation. (A. the scaffold, computer-designed prototype; B and C. the scaffold, the cross-sectional and vertical views, by scanning electron microscopy; D. the cartoon sculpture presenting a scaffold in the calvaria defect of the rat; E and F, the scaffolds implanted into the defects in rats) (PCL: poly-caprolactone; PRF: plasma rich fibrin; and PCF + PCL: PCL-plus-PRF).
