Figure 4.

The differential taxa at different taxonomic levels (phylum, class, order, family, and genus) of the caries-active (CA, blue), periodontitis (P, red), caries-active and periodontitis (CAP, yellow) saliva in comparison with healthy controls (H, brown). (A) The significant taxa were tested by LEfSe (LDA score > 2.0) and showed using the cladogram. The cladogram graphically represents the discovered biomarkers in a taxonomic tree specified by the hierarchical feature names. (B) Pearson's correlations of differentially abundant genera among the four microbial communities. The colors of the circles represent the directions of the correlations, and their sizes correspond to the significance of the P values (the larger the circle, the smaller the P value and thus, the higher the significance).