Table 2.
Comparisons of frequencies of blood hemoglobin (Hb), iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody (GPCA) positivity between 46 burning mouth syndrome (BMS) patients with macrocytosis (MCV ≥ 100 fL) and 442 healthy control subjects or 884 BMS patients.
| Group | Patient number (%) |
|||||
|---|---|---|---|---|---|---|
| Hb deficiency (Men < 13 g/dL, women < 12 g/dL) | Iron deficiency (<60 μg/dL) | Vitamin B12 deficiency (<200 pg/mL) | Folic acid deficiency (<4 ng/mL) | Hyperhomocysteinemia (>12.3 μM) | GPCA positivity | |
| BMS patients with macrocytosis (n = 46) | 30 (65.2) | 11 (23.9) | 22 (47.8) | 0 (0.0) | 28 (60.9) | 21 (45.7) |
| aP-value | <0.001 | <0.001 | <0.001 | NA | <0.001 | <0.001 |
| bP-value | <0.001 | 0.241 | <0.001 | 0.610 | <0.001 | <0.001 |
| cBMS patients (n = 884) | 175 (19.8) | 143 (16.2) | 42 (4.8) | 20 (2.3) | 170 (19.2) | 109 (12.3) |
| cHealthy control subjects (n = 442) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 11 (2.5) | 8 (1.8) |
NA = not assessed.
a
Comparisons of frequencies of parameters between 46 BMS patients with macrocytosis and 442 healthy control subjects by chi-square test.
b
Comparisons of frequencies of parameters between 46 BMS patients with macrocytosis and 884 BMS patients by chi-square test.
c
The blood examination data of 884 BMS patients and 442 healthy control subjects were retrieved from our previous study.9