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. 2021 Jun 29;10(4):761–770. doi: 10.1093/toxres/tfab060

Table 2.

Oral drug-likeness of the tetrahydrocannabinol, nicotine, and alcohol using Lipinski rule of five filters

Compound Molecular weight (Dalton) Log P Number of HBD Number of HBA Molar refractivity Number of rotatable bonds
Tetrahydrocannabinol 314.46 1.7903 1 2 97.91 4
Nicotine 162.23 1.2663 0 2 53.13 1
Alcohol 46.07 1.3617 1 1 12.89 0

HBD, hydrogen bond donor; HBA, hydrogen bond acceptor.