Table 3.
ADMET properties of the tetrahydrocannabinol, nicotine, and alcohol predicted from admetSAR
| ADMET | Tetrahydrocannabinol | Nicotine | Alcohol |
|---|---|---|---|
| BBB | Yes | Yes | No |
| GI absorption | High | High | No |
| Ames toxicity | No | No | No |
| Carcinogenicity | No | No | No |
| Pgp | No | No | No |
| CYP 2C19 inhibitor | Yes | No | No |
| CYP 2C9 inhibitor | Yes | No | No |
| CYP 1A2 inhibitor | No | No | No |
| CYP 2D6 inhibitor | Yes | No | No |
| CYP 3A4 inhibitor | No | No | No |
| Skin permeation | −3.27 cm/s | −6.46 cm/s | −6.64 cm/s |
BBB, blood brain barrier; CYP, cytochrome; GI absorption, gastrointestinal absorption; Pgp, permeability glycoprotein.