Fig. 6.

Wnt signaling induces KIF2A interaction with and activation by PLK1 to promote congression and alignment of chromosomes during mitosis. Scheme of the suggested model for Wnt modulating chromosome congression in mitosis. Basal Wnt signaling during G2/M induces DVL clustering in LRP6 signalosomes, which serves as platforms for PLK1 and KIF2A interaction. Downstream of PLK1, phosphorylation of KIF2A at S100 by an unknown kinase further stabilizes the interaction, leading to KIF2A activation and transfer to the spindle poles. Finally, by monitoring KIF2A at the mitotic spindle, Wnt signaling ensures timely chromosome congression and alignment in mitosis.