FIGURE 6.

Impact of the rate of the first step of each pathway on Rc_‐IF at equilibrium. Microscopic rate constants k₁ and k₂ are changed 10‐fold in tandem for a single pathway of Case A. The impact thereof on the Rc_‐IF is also shown for Case B in Supporting Information Section S5. (A) Left side: Decreasing or increasing the value of the k_1CS–k_2‐CS tandem shifts the ascending portion of the Rc_‐IF versus [L] plots in the same way (i.e., to lower and higher [L], respectively) without affecting Rc_‐IF at low [L]. Right side: The horizontal shifts can be related to the ability of F_on‐CS to start descending at lower and higher [L], respectively. The more complex link between k_1CS and the shifts is further documented in Supporting Information Section S6. (B) Left side: Decreasing or increasing the value of the k_1IF–k_2‐IF tandem does not affect the Rc_‐IF versus [L] plots. Left side: the F_on‐IF versus [L] plots are not affected either