Fig. 6. SI-12 significantly inhibits breast cancer metastasis in mouse models.
A. Bioluminescent images showed progression of breast cancer lung metastasis w/o SI-12 (4mg/kg/day) treatment in spontaneous metastasis model developed from fat pad injection of MDA-MB-231 cells. B. Luciferase activities in lung lysis were examined at the end of treatment. C. Bioluminescent images showed progression of metastasis growth established from tail vein injection of LM2 cells w/o SI-12 (10mg/kg/day) treatment. D. Luciferase activity in lung was monitored during SI-12 treatment in LM2 lung metastasis mice. E. Luciferase activities in lung lysis from LM2 model was examined at the end of treatment. *p<0.05, **p<0.01