Table 1.

Blood and urine biochemistry

		Baseline only	Baseline and weeks 4, 8, 12, 16, 20 and 24
Blood	Safety	Haemoglobin Platelets White blood cell count Absolute neutrophil count Urate Albumin Bilirubin Alanine aminotransferase Alkaline phosphatase Glucose Parathyroid hormone	Calcium Phosphate Magnesium Sodium Potassium Urea Creatinine High- and low-density lipoproteins Total cholesterol
	Research		Parathyroid hormone (including 1-34 and other fragments) Cyclic adenosine monophosphate Vitamin D metabolites Bone remodelling compounds:  Carboxyl-terminal collagen cross-links  Procollagen type 1 N-terminal propeptide  Sclerostin  Osteoprotegerin  Receptor activator of nuclear factor kappa-B ligand  Dickkopf-related protein 1  Fibroblast growth factor 23 Butyrate
Urine	Safety		Calcium Phosphate
	Research		Pyridinoline Deoxypyridinoline Oxalate Cyclic adenosine monophosphate

Additional bone remodelling compounds may be analysed if assay methodologies are validated during the trial