Table 1. Cytotoxicity Determined by MTT Assay in Murine CT26 and Human HCT116 Colon Cancer Cells after 48 h Incubation with and without 5 equiv AAa.
| +AA | |||
|---|---|---|---|
| mean ± SD | mean ± SD | ratio | |
| CT26—IC50 Values (μM)—48 h | |||
| oxaliplatin | 1.50 ± 0.39 | 1.53 ± 0.25 | 0.98 |
| OAc/OAc | 25.66 ± 1.40 | 22.60 ± 0.16 | 1.14 |
| SucCa/OAc | 75.21 ± 0.11 | 28.17 ± 1.81 | 2.67 |
| SucEs/IdoCa | >100 | 26.65 ± 0.75 | ≥3 |
| SucCa/IdoCa | >100 | 38.84 ± 3.84 | ≥2.6 |
| SucEs/IdoEs | 91.51 ± 3.84 | 11.15 ± 0.37 | 8.21 |
| SucCa/IdoEs | 60.09 ± 6.49 | 10.81 ± 1.04 | 5.56 |
| HCT116—IC50 Values (μM)—48 h | |||
| oxaliplatin | 0.72 ± 0.01 | 0.67 ± 0.01 | 1.07 |
| OAc/OAc | 26.56 ± 2.41 | 20.10 ± 1.57 | 1.32 |
| SucCa/OAc | >100 | 33.96 ± 1.58 | ≥2.9 |
| SucEs/IdoCa | >100 | 35.39 ± 6.54 | ≥2.8 |
| SucCa/IdoCa | >100 | 43.27 ± 2.10 | ≥2.3 |
| SucEs/IdoEs | 22.80 ± 1.15 | 6.94 ± 0.33 | 3.28 |
| SucCa/IdoEs | 26.00 ± 3.21 | 7.36 ± 1.14 | 3.53 |
a
Values are given as mean ± standard deviation (SD).