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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Eur J Pharm Sci. 2021 Mar 27;162:105821. doi: 10.1016/j.ejps.2021.105821

Fig. 2.

Fig. 2.

DYRK1A and MAO-A dose response curves for selected harmine-related hits. Dose response curves for β-carbolines in (A) DYRK1A TR-FRET assay and (B) DYRK1A 33P-ATP assay. (C) Correlation of IC50 values between DYRK1A TR-FRET and 33P-ATP assays, linear regression fit. (D) Dose response curves for β-carbolines in MAO-A assay. Color key for harmine-like compounds in all 3 assays shown to the right of panel (B). For each concentration (10 point) run in duplicate, percent inhibition values were calculated and data normalized to controls. Dose response curves were generated using non-linear regression and IC50 values determined in GraphPad Prism 7.