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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Eur J Pharm Sci. 2021 Mar 27;162:105821. doi: 10.1016/j.ejps.2021.105821

Fig 4.

Fig 4.

Effect of harmine and harmol on glioma cancer cell proliferation. (A) H4 and U87 cells were incubated with harmine and harmol (0.0001 – 25 μM) for 72 h, and proliferation assessed by Presto Blue. For each concentration, percent inhibition values were calculated and data normalized to vehicle. Dose response curves were generated using non-linear regression and IC50 values determined in GraphPad Prism 7. (B) Correlation of IC50 values between DYRK1A TR-FRET and H4 proliferation assays, linear regression fit. Dose response curves for the other analogs are shown in the accompanying Data in Brief article (Tarpley et al. 2021b).