Table 1.

DYRK1A IC₅₀ values (μM) for the identified β-carbolines.

Compound	TR-FRET	33P-ATP a	Published values b
Harmine	0.07	0.009	0.022 – 0.107
Harmaline	2.35	0.79	1.236 – 4.59
Harmalol	0.63	0.18	Undetermined
Harmol	0.10	0.016	0.044–0.298
Harmane	2.68	1.00	1.82
Tetrahydroharmine	9.41	6.42	2.987
Norharmane	5.46	3.19	8.746
Staurosporine		0.002

^a33P-ATP data generated by Reaction Biology Inc.

^b(Adayev et al., 2011; Bain et al., 2007; Bálint et al., 2017; Bruel et al., 2014; Foucourt et al., 2014; Göckler et al., 2009; Grabher et al., 2012; Kim et al., 2016; Kumar et al., 2018; Liu et al., 2017b) Details in Supplementary Table 1; additional values from National Center for Biotechnology Information; PubChem Database.