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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Eur J Pharm Sci. 2021 Mar 27;162:105821. doi: 10.1016/j.ejps.2021.105821

Table 3.

Cell viability IC50 values (μM) for harmine analogs.

Compound H4
(cell proliferation) a 		H4
(nuclear count) b 		U87
(cell proliferation) a 		U87
(nuclear count) b
Harmine 4.9 14.91 45.3 17.6
Harmaline 19.6 14.87 14% c ~66% c
Harmalol 23.7 25.2 37% c <50% c
Harmol 10.9 20.0 19.1 20.8
Harmane 33.5 17.1 30% c ~50% c
Tetrahydroharmine 38%c 26.9 No inhibition c ~50% c
Norharmane 49 29.1 No inhibition c No inhibition c
a

PrestoBlue cell viability assay.

b

Hoechst 33342 high content imaging assay.

c

% inhibition at highest dose tested.