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. 2021 Aug 30;19:372. doi: 10.1186/s12967-021-02979-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — mRNA overexpression of LANCL2 and EGFR was common in GBM specimens of TCGA database, but was not associated with prognosis of GBM patients. A, B mRNA expression levels of LANCL2 and EGFR in 32 different cancers of TCGA Pan-Cancer Atlas database. C Frequencies of LANCL2 and EGFR mRNA overexpression in two TCGA studies of GBM and LGG. D Frequencies of LANCL2 and EGFR mRNA overexpression in different pathological types of gliomas. E, F The correlations between CNVs and mRNA expression of LANCL2 or EGFR in GBM. P values were determined by Kruskal–Wallis One-Way ANOVA and Dunn’s multiple comparisons. ***p < 0.001. G Frequencies of concurrent mRNA overexpression of LANCL2 and EGFR in total or EGFR-overexpressed GBM samples. H A significant association between the mRNA expression levels of LANCL2 and EGFR in GBM. I Forest plot showing the univariate analysis for OS according to the mRNA expression of LANCL2 and EGFR in GBM patients of TCGA database. P values and hazard ratios were determined by log-rank test