Table 3.
Relationship between the timing of initial FET after a fresh IVF-ET attempt failure and pregnancy outcomes in different models
| Pregnancy outcomes | Timing of initial FET | Crude model a | Adjusted model I b | Adjusted model II c | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
| Positive pregnancy | Immediate FET group | Reference | Reference | Reference | |||
| Delayed FET group | 1.09 (0.80to 1.48) | 0.587 | 1.04 (0.75 to 1.44) | 0.810 | 0.95 (0.67 to 1.35) | 0.781 | |
| Clinical pregnancy | Immediate FET group | Reference | Reference | Reference | |||
| Delayed FET group | 0.74 (0.54 to 1.02) | 0.066 | 0.70 (0.50 to 0.97) | 0.031 | 0.68 (0.47 to 0.97) | 0.031 | |
| Ongoing pregnancy | Immediate FET group | Reference | Reference | Reference | |||
| Delayed FET group | 0.78 (0.55 to 1.05) | 0.096 | 0.71 (0.51 to 0.99) | 0.048 | 0.68 (0.47 to 0.99) | 0.041 | |
| Live birth | Immediate FET group | Reference | Reference | Reference | |||
| Delayed FET group | 0.75 (0.54 to 1.04) | 0.080 | 0.70 (0.50 to 0.98) | 0.038 | 0.67 (0.46 to 0.96) | 0.031 | |
Abbreviation: AMH Anti-müllerian hormone, BMI Body mass index, FSH Follicle stimulating hormone, OR Odds ratio, CI Confidence interval, FET Frozen embryo transfer, IVF-ET In vitro fertilization-embryo transfer, AFC Antral follicle count, COS Controlled ovarian stimulation; Gn, gonadotropin
a No adjustments for other covariates
b Adjusted for female age (< 35 yrs., ≥ 35 yrs.), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)
c Adjusted for female age (< 35 yrs., ≥ 35 yrs.), AMH (< 1.2 ng/ml, ≥ 1.2 ng/ml), BMI (< 24 kg/m2, ≥ 24 kg/m2), basic FSH (< 10 UI/L, ≥ 10 UI/L), AFC (< 10, ≥ 10), endometrial thickness before FET, No of oocytes retrieved (≤ 9, > 9), No of transferred frozen thawed embryos (single, double), method of fertilization (IVF, ICSI), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)