FIG. 1.

Esa1p has sequence similarity (gray boxes) with human Tip60 and D. melanogaster MOF. A region of strong sequence similarity to acetyltransferases including yeast Hat1p and Gcn5p is indicated (black boxes). Similar and identical residues in this region are highlighted. Residues most conserved among known and predicted acetyltransferases in the A motif as defined by Neuwald and Landsman (42) are noted with asterisks. Positions of temperature-sensitive esa1 alleles (see text) are noted by arrows above the Esa1p cartoon; the position of the esa1-L327S allele is also shown by an arrow in the sequence expansion. The conserved G→E mutation in mof (25) is marked with an arrowhead below the sequence. An N-terminal chromo domain (1, 25, 31, 47) is found in these three SAS family members (diagonal stripes). The number of amino acids in each protein is indicated at the right.