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. 2021 Aug 26;9(8):e003132. doi: 10.1136/jitc-2021-003132

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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SVMAV reduced the pulmonary metastasis of melanoma. (A) Schematic of the vaccination scheme and tumor challenge. (B) Photographs of lung tissues excised on day 37; red arrows highlight metastatic foci. (C) Histogram showing the numbers of lung metastases in different groups. (D) Representative H&E staining and Ki-67 IHC staining results of lung sections from different groups. *P<0.05. Black scale bar represents 100 µm (magnification, ×100). IHC, immunohistochemistry; SVMAV, Self-assembling Vehicle-free Multi-component Antitumor nanoVaccine.