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SPEG phosphorylation of RyR2-S2367 inhibits diastolic Ca2+ leak. While CaMKII phosphorylation (P) of S2814 and PKA phosphorylation of S2808 and S2030 have been shown to enhance RyR2 diastolic opening, enhanced targeting by protein phosphatase 1 and 2 (PP1 and PP2) along with phosphorylation of S2367 by SPEG inhibit diastolic Ca2+ leak.
