Figure 1.
Biological networks and basic network components. (A) Biological networks can represent a wide spectrum of biological dimensions. (B) In biological networks, distinct biological components, such as genes or metabolites, are represented as individual nodes. Edges connect two nodes and represent the interaction between them. Hubs are defined as nodes that are highly connected to other nodes. When a node and its neighbours are highly connected to one another, the resulting network neighbourhood is defined as a cluster or network submodule. Adapted from refs5–7 with permission.