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. 2021 Aug 23;220(10):e202012001. doi: 10.1083/jcb.202012001

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© 2021 Mori et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — Spatial separation of maternal and paternal chromosomes prevents the production of aneuploid zygotes. (A) Live imaging of chromosomes (mCherry-MBD-NLS) in eggs in which sperm heads were injected within the 20-µm region surrounding maternal chromosomes. Four phenotypes were observed: move away, polar body, fusion, and center. In the center type, paternal chromosomes are not localized at the periphery of the zygote and move randomly in the cytoplasm. Time is relative to the appearance of the sperm signal. Time-lapse video of polar body and fusion are shown in Video 6. The zona pellucida was softened by treatment with glutathione (A and B). (B) Percentage of phenotypes in eggs in which sperm heads were injected outside or inside the 20-µm region surrounding maternal chromosomes. Right panel shows where sperm heads were injected. The values of the positions were normalized by the length between maternal chromosomes and the center of the egg when the paternal chromosome signal appeared.