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. 2021 Aug 23;220(10):e202012001. doi: 10.1083/jcb.202012001

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© 2021 Mori et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 8. — Schematic of the mechanism by which zygotes regulate the localization of paternal chromosomes. RanGTP signaling and F-actin dynamics play central roles in spatially separating paternal chromosomes from maternal chromosomes in zygotes. On the plasma membrane before fertilization, RanGTP regulates Juno/CD9 structures and blocks egg–sperm fusion in proximity to maternal chromosomes. In the cytoplasm, following egg–sperm fusion, F-actin keeps paternal chromosomes away from maternal chromosomes.