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. 2021 Aug 24;220(10):e202101019. doi: 10.1083/jcb.202101019

Figure 2.

Figure 2.

TDPΔCR mice exhibit characteristic behavioral abnormalities. (A) Representative images and quantification of nestlet shredding of WT and TDPΔCR+/− mice (n = 14 mice per group). (B) Representative images and quantification of marble-burying activity of WT mice (n = 17) and TDPΔCR+/− mice (n = 16). (C) Representative track plots and quantification of WT mice (n = 19) and TDPΔCR+/− mice (n = 16) in the light/dark box task. (D) Representative images and quantification of WT mice (n = 9) and TDPΔCR +/− mice (n = 12) in the tail suspension test. (E) Performance of WT mice (n = 11) and TDPΔCR+/− mice (n = 12) in the Y-maze test. (F) Left: Representative track plots of WT and TDPΔCR mice in the second trial at day 5. Right: Quantification of the Barnes maze performance of WT mice (n = 12) and TDPΔCR+/− mice (n = 20) over 5 d of successive testing (two trials/day). Data are mean ± SEM; two-tailed Student’s t test (A–E) or two-way ANOVA followed by Bonferroni multiple comparisons test (F). *, P < 0.05; **, P < 0.001; and ****, P < 0.0001.