Table 5.
Safety assessment of PPC and MgIG for treatment of DILI.
| Variables | PPC groupN = 183 | MgIG groupN = 183 | p |
|---|---|---|---|
| Outcome after treatment, n (missing) | 183 (0) | 183 (0) | >0.05 |
| Cured and fully relieved | 162 (88.52%) | 153 (83.61%) | |
| Worse | 6 (3.28%) | 4 (2.19%) | |
| Death | 2 (1.09%) | 1 (0.55%) | |
| Unchanged | 4 (2.19%) | 4 (2.19%) | |
| Unknown | 9 (4.92%) | 21 (11.48%) | |
| Cr change (normal → abnormal), n (missing) | 79 (0) | 117 (0) | 0.1913 |
| Yes | 5 (6.33%) | 3 (2.56%) | |
| No | 74 (93.67%) | 114 (97.44%) | |
| Cr change (abnormal → worse), n (missing) | 27 (0) | 6 (0) | 0.4916 |
| Yes | 2 (7.41%) | 0 (0.00%) | |
| No | 25 (92.59%) | 6 (100.00%) | |
| Cr change (normal → abnormal & abnormal → worse), n (missing) | 106 (0) | 123 (0) | 0.1241 |
| Yes | 7 (6.60%) | 3 (2.44%) | |
| No | 99 (93.40%) | 120 (97.56%) | |
| BUN change (normal → abnormal), n (missing) | 89 (0) | 96 (0) | 0.5393 |
| Yes | 3 (3.37%) | 5 (5.21%) | |
| No | 86 (96.63%) | 91 (94.79%) | |
| BUN change (abnormal → worse), n (missing) | 14 (0) | 20 (0) | 0.3475 |
| Yes | 2 (14.29%) | 1 (5.00%) | |
| No | 12 (85.71%) | 19 (95.00%) | |
| BUN change (normal → abnormal & abnormal → worse), n (missing) | 103 (0) | 116 (0) | 0.9143 |
| Yes | 5 (4.85%) | 6 (5.17%) | |
| No | 98 (95.15%) | 110 (94.83%) | |
| WBC change (normal → abnormal), n (missing) | 130 (0) | 125 (0) | 0.9233 |
| Yes | 11 (8.46%) | 11 (8.80%) | |
| No | 119 (91.54%) | 114 (91.20%) | |
| WBC change (abnormal → worse), n (missing) | 50 (0) | 47 (0) | 0.9272 |
| Yes | 4 (8.00%) | 4 (8.51%) | |
| No | 46 (92.00%) | 43 (91.49%) | |
| WBC change (normal → abnormal & abnormal → worse), n (missing) | 180 (0) | 172 (0) | 0.8964 |
| Yes | 15 (8.33%) | 15 (8.72%) | |
| No | 165 (91.67%) | 157 (91.28%) | |
| Hb change (normal → abnormal), n (missing) | 117 (0) | 113 (0) | 0.5868 |
| Yes | 14 (11.97%) | 11 (9.73%) | |
| No | 103 (88.03%) | 102 (90.27%) | |
| Hb change (abnormal → worse), n (missing) | 63 (0) | 56 (0) | 0.1303 |
| Yes | 0 (0.00%) | 2 (3.57%) | |
| No | 63 (100.00%) | 54 (96.43%) | |
| Hb change (normal → abnormal & abnormal → worse), n (missing) | 180 (0) | 169 (0) | 0.9762 |
| Yes | 14 (7.78%) | 13 (7.69%) | |
| No | 166 (92.22%) | 156 (92.31%) | |
| PLT change (normal → abnormal), n (missing) | 137 (0) | 122 (0) | 0.7986 |
| Yes | 9 (6.57%) | 9 (7.38%) | |
| No | 128 (93.43%) | 113 (92.62%) | |
| PLT change (abnormal → worse), n (missing) | 42 (0) | 47 (0) | 0.0623 |
| Yes | 3 (7.14%) | 0 (0.00%) | |
| No | 39 (92.86%) | 47 (100.00%) | |
| PLT change (normal → abnormal & abnormal → worse), n (missing) | 179 (0) | 169 (0) | 0.5894 |
| Yes | 12 (6.70%) | 9 (5.33%) | |
| No | 167 (93.30%) | 160 (94.67%) | |
| ALB change (normal → abnormal), n (missing) | 91 (0) | 100 (0) | 0.6105 |
| Yes | 8 (8.79%) | 11 (11.00%) | |
| No | 83 (91.21%) | 89 (89.00%) | |
| ALB change (abnormal → worse), n (missing) | 41 (0) | 35 (0) | |
| Yes | 41 (100.00%) | 35 (100.00%) | |
| ALB change (normal → abnormal & abnormal → worse), n (missing) | 132 (0) | 135 (0) | 0.5071 |
| Yes | 8 (6.06%) | 11 (8.15%) | |
| No | 124 (93.94%) | 124 (91.85%) |
PPC, polyene phosphatidylcholine; MgIG, magnesium isoglycyrrhizinate; DILI, drug induced liver injury; Cr, creatinine; BUN, blood urea nitrogen; WBC, white blood cell; Hb, hemoglobin; PLT, platelet; ALB, albumin.