FIG 4.

Fates of oxoG in vivo. The scheme depicts four alternate fates of oxoG, representing different processing pathways and biological consequences. Thus, repair avoids the deleterious consequences of oxoG if it can be completed before DNA replication, and unrepaired oxoG may be bypassed accurately by TLS. If both these options fail, bypass by the remaining polymerases has low accuracy (leading to transversion) and low efficiency (promoting cell death). (A) Predominance of repair and accurate TLS within normal S. acidocaldarius cells. (B) Cells lacking ogg activity, in which the proportion of erroneous TLS increases. (C) Consequences of losing both Ogg and Dbh activities.