Figure 3. Proteomic clustering of ten body fluids. (A) The consensus clustering analysis of ten body fluids identified four clusters. The heatmap depicts the relative abundance of the signature proteins in four subtypes (Z score of iBAQ). (B) A bubble plot of the KEGG pathway enrichment of C-I, C-II, C-III, and C-IV is shown. (C) Diagram summarizes the differentially expressed signatures and signaling cascades involved in C-I to CIV. The heatmap under each protein depicts the Z score of average protein abundance in each proteomic subtype. CSF: Cerebrospinal fluid; KJF: knee-joint fluid; ECM: extracellular matrix; KEGG: Kyoto Encyclopedia of Genes and Genomes; TCA: tricarboxylic acid cycle.