Figure 4. Antitumor effects of adipose tissue-derived mesenchymal stem cells (ASCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in xenograft animal models. A: Changes in the tumor volume of mice after ASC transplantation. The tumor volume was measured using Vernier calipers at the indicated time-points (for 3 weeks) after the transplantation of H460 cells alone, or together with ASCs, ASC-TRAIL, and ASC-interferon (IFN)-β. The data are expressed as the mean±SE (n=10 per group). B: Tumor weight 3 weeks after the transplantation of H460 cells alone, and together with ASCs, ASC-TRAIL, or ASC-IFN-β. The data are expressed as the mean±SE (n=10 per group). C: Tumor morphology. Three weeks after the injection of H460 cells alone, or together with ASCs, ASC-TRAIL, and ASC-IFN-β, the mice (n=10 per group) were sacrificed by cervical dislocation and the tumor masses were separated and photographed. Significantly different at *p≤0.05.