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[Preprint]. 2021 Aug 26:2021.08.25.457693. [Version 1] doi: 10.1101/2021.08.25.457693

Figure 7. Low dose mRNA vaccine protection against lung inflammation and pathology in K18-hACE2 transgenic mice.

Figure 7.

Seven to nine-week-old female K18-hACE2 transgenic mice were immunized, boosted with 0.25 μg of mRNA vaccines (control, mRNA-1273, or mRNA-1273.351, and challenged with WA1/2020, WA1/2020 N501Y/D614G, B.1.1.7/E484K, B.1.351, or B.1.617.2. as described in Figure 5. Hematoxylin and eosin staining of lung sections harvested at 6 dpi or from an uninfected animal. Images show low- (top; scale bars, 1 mm) and high-power (bottom; scale bars, 50 μm). Representative images of multiple lung sections from n = 2 per group.