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RTL3 modulates SOX-9 expression through interactions with the zinc finger CCHC binding domain. (A) mRNA expression of RTL3 was increased upon transfection with the ΔRTL3 plasmid. (B) Immunoblotting with anti-RTL3 Novus antibody confirmed production of the truncated ΔRTL3 protein. Transfection with ΔRTL3 did not affect cell viability (C) and did not induce chondrocyte mRNA expression of SOX-9 (D) or of COL2A1 (E) nor increase the COL2A1 promoter reporter activity (F).
