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. 2021 Jun 15;183(1):154–169. doi: 10.1093/toxsci/kfab075

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Increased sensitivity of Tiparp^H532A mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatotoxicity and lethality. A, Kaplan-Meier survival curves for Tiparp^+/+ treated with 100 µg/kg, and Tiparp^H532A mice treated with a single injection of 10 (in blue) or 100 µg/kg (in red) TCDD (n = 4–6). B, % body weight relative to pretreatment (C) liver somatic index, (D) serum alanine aminotransferase activity, (E) thymus somatic index, and (F) epididymal white adipose tissue somatic index at the days (d) indicated (n = 4–6). *p < .05 2-way analysis of variance (ANOVA) followed by Sidak’s post hoc test compared with genotyped-matched control-treated mice. ^#p < .05 2-way ANOVA followed by Sidak’s post hoc test compared with time-matched TCDD-treated Tiparp^+/+ mice. Figure depicts the mean ± SEM.