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. 2021 Jun 3;183(1):81–92. doi: 10.1093/toxsci/kfab068

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Figure 7. — Representative photomicrographs of liver histopathology. A, Hepatic fatty change (steatosis) in a PPARA-humanized mouse liver after 5 weeks of dietary GW7647 administration. B, Hepatic necrosis in a wild-type mouse liver after 26 weeks of GW7647 administration. C, Hepatocellular adenoma in a wild-type mouse liver after long-term dietary GW7647 administration. D, Hepatocellular carcinoma in a control Ppara-null mouse liver after long-term administration of GW7647. E, Hepatocellular carcinoma in a control PPARA-humanized mouse liver. Note fatty change. F, Hepatocellular carcinoma in a PPARA-humanized mouse liver after long-term administration of GW7647. Magnification = 40×.